And there came one of the seven angels who had the seven vials and spoke with me [Apostle John], saying: Come, I will shew thee the condemnation of the ‘great harlot’ who sitteth upon many waters: (Rev. 17:1, DRCB) 

At dumating ang isa sa pitong anghel na may pitong mangkok, at nagsalita sa akin, na nagsasabi, Pumarito ka, ipakikita ko sa iyo ang hatol sa bantog na patutot na nakaupo sa maraming tubig; (Rev. 17:1, TCB)    

And there came one of the seven angels which had the seven vials, and talked with me [Apostle John], saying unto me, Come hither; I will shew unto thee the judgment of the ‘great whore’ that sitteth upon many waters: (Rev. 17:1, KJB)   

The following quote helps to establish the time frame of Revelation 17:1… 

[BEGIN QUOTE] - The expression "which had the seven vials," would seem to imply that though they [the seven angels] had [already] emptied the vials in the manner stated in the previous chapter [chapter 16], they still retained them in their hands. And talked with me - Spake to me. . . . . ‘Come hither” . . . . This is a word merely calling the attention, as we should say now, "[Come] Here." It does not imply that John was to leave the place where he was [Isle of Patmos] . . . . “I will shew unto thee”- Partly by symbols, and partly by express statements; for this is the way in which, in fact, he showed him. The judgment - The condemnation and calamity that will come upon her [the “Great Harlot”. [END QUOTE] ^[1]

The ‘Great Harlot’ [‘Great Whore’] symbolizes the APOSTATE [the perversion of true Christianity with a mix of paganism] ‘ONE WORLD CHURCH’ [a ‘Worldwide Idolatrous Religious System’], that is already being formed through the process of Religious Ecumenism, and that will come into full existence during the first 3-1/2 years of the Seven Year Tribulation Period.  Idolatrous worship is frequently represented as a “whore” in the Bible, i.e., see Ezekiel 16:1-63; Ezekiel 23:1-49, etc.)                      

Please note here that the “Great Harlot” is “sitting upon many waters”, which is interpreted by the angel to Apostle John in Revelation 17:15 as being… “peoples, and multitudes, and nations, and tongues”…meaning that the “Great Harlot’s idolatrous forms of worship” already has great influence over the entire earth! 

Most importantly in Revelation 17:1, the angel is going to show Apostle John in a vision the DESTRUCTION of the “Great Harlot” [the One World Religious System] that will take place towards the end of the FIRST 3-1/2 YEARS of the Seven Year Tribulation Period.—We know this to be true because the world will be required to worship Antichrist only during the SECOND 3-1/2 YEARS  of the Seven Year Tribulation Period.

END NOTES[1] BIBLE HUB, Gill’s Exposition of the Entire Bible, Revelation 17:1, Accessed August 8, 2024, Web: https://biblehub.com/commentaries/revelation/1